For six-axle (2C0) 200 km/h high-power electric passenger locomotive with spring bogie suspension, a dynamic locomotive model was established with the multiple rigid body dynamics software of SIMPACK. Dynamic analysis of locomotive damper fault state at different speed was provided, and the highest locomotive operating speed of high-interference irregular railway was calculated. Results shows that the locomotive can not reach the speed of 160 km/h only when the yaw damper fails, the wheels are worn to a maximum or both secondary vertical dampers of bogies fail; lateral damper has the least effects to the dynamic performance of the electric locomotive, whereas the yaw damper, the secondary vertical damper and the motor damper impose relatively greater effects.