As the axle weight of the locomotive continues to increase, the wheel-rail wear is intensified, and rail corrugation on the small radius curve becomes more and more common. Based on the theory of vehicle system dynamics, by establishing C,0,-C,0, 30 t axle heavy haul locomotive model, and using MATLAB software to simulate rail corrugation on the small radius curve as the external disturbance input, the influence of the small radius curve with rail corrugation on locomotive curve passing safety of heavy haul railway was studied. The results showed that the vertical force of the wheel-rail increased with the increasing of the wave depth, and decreased with the increasing of the wavelength. When the locomotive passed the small radius curve rail at a speed of not less than 70 km/h, it was highly probable that the wheel and rail would be instantaneously detached. In order to ensure the safety of the locomotive curve passing, the dynamic wheel load shedding rate, derailment coefficient and overturning coefficient were used as evaluation indexes. For the rail corrugation of different wave depths and wavelengths, the driving speed was proposed, that is, for rail corrugation with wave length of 300 mm and wave depth of 0.8 mm, the safe passing speed of locomotive couldn’t exceed 70 km/h; when rail corrugation is further developed and wave depth reaches 1.0 mm, the safe passing speed of locomotive couldn’t exceed 60 km/h.