From the perspective of vehicle design and optimization of system dynamics parameters, a method for optimizing the guidance performance of suspended monorail vehicles was explored. Firstly, the structure of the suspended monorail vehicle was analyzed. On this basis, the suspension monorail vehicle topological configuration relationship and dynamic simulation model based on multi-body dynamics were established. Then, the sensitivity analysis of the system dynamics parameters of the suspended monorail vehicle was performed, and the parameters that have significant influence on the steering torque of the suspended monorail vehicle were selected. Finally, the influence of significant system dynamics parameters was taken as the optimal design variables, the vehicle curve passability and stationarity were taken as the optimization constraints, the NSGA-II genetic algorithm was used as the optimization algorithm, the multi-body dynamics software (ADAMS) and multi-objective optimization software (modeFRONTIER)were combined to optimize the steering torque of the suspended monorail vehicle, and the effectiveness and feasibility of the optimization results were verified. The optimization results show that under the given constraints, when the vertical stiffness of the air spring, the transverse stiffness of the air spring, the vertical stiffness of the running wheel, the side-bias stiffness of the running wheel, and the radial stiffness of the guide wheel reached the optimal solution, the steering torque of the suspended monorail vehicle was reduced by 26.57%~38.57%, and the guiding performance of the suspended monorail vehicle has been effectively improved.