In order to solve the abnormal wheelsets wear of some metro vehicles after long-term operation, the abnormal wheelsets wear caused by poor electro-pneumatic braking coordination and signal control instruction error of metro vehicles was investigated and analyzed. The improvement measures of modifying software control logic to reduce the supplement of the air braking of metro vehicles at 65 km/h was proposed, and the control of air brake system and automatic driving mode control software were optimized. Practical application showed that the improvement measures had obvious effect and solved the abnormal wear problem of metro vehicle wheelsets.