Necessity and principle of seismic mitigation and isolation design for high-speed railway bridges were expounded, and the norms and standards of seismic mitigation and isolation design both in domestic and overseas industry as well as its most popular devices were introduced,and progress on commonly used seismic mitigation and isolation devices in China. Based on scaled mode of simply support beam girder bridge that commonly applied in China, a typical pendulum and viscous fluid damper were designed and shaking table tests were carried out on middle & low pier separately, which illustrated that those devices had better performance than common spherical bearing in terms of seismic mitigation and isolation. In particular, pendulum was quite suitable for low-pier structure while viscous fluid damper for high-rise and flexible piers. Finally, the paper reviewed the key points for design, such as shear-keys design for pendulum and design attentions for viscous damper.