Measuring wheel profile parameters is very important for the safety of running trains. Inspection of wheel profile parameters with laser light image was the mainstream technology. Under high-speed conditions, however, the tradition dynamic inspection system for wheel profile of railway vehicles couldnot meet the precision demand in several aspects, such as system layout, mechanical design, image quality of camera so on. Several solutions for the dynamic inspection system for wheel profile parameters in calibration algorithm, system design aspects were proposed, which ensured that system precision reached the standard in high speed situations.