On the basis of analyzing the current situation of the security and reliability of the high-speed train system at home andabroad, a complete set of system security and reliability analysis method system and evaluation process for the high-speed train was putforward, and the reliability analysis method of reliability network model and security domain risk assessment was deeply studied. Themethod and its evaluation process were verified based on the actual data of China’s CRH2 high-speed train, promoting the formation ofChina’s high-speed train safety reliability analysis and evaluation standard which was compatible to international standards, as well asproviding technical support for the design and operation of high-speed train′s safety and reliability.