According to the mechanical characteristics of frame actual operations, four supernormal conditions were obtained and simulated for the static strength. The results showed that the maximum von-Mises stress was 118.181MPa, locating in the connection of stabilizing wheel and frame, which less than 293MPa, the allowable maximum stress of material Q345A. Furthermore, dynamic stress values of frame measuring points was analyzed, which measured by FAMOS in normal operation of traction curve condition. By substituting the value in Goodman fatigue limit diagram and analyzing fatigue strength, the maximum and minimum stress and stress amplitude of measurement points were proved within the range of allowable material fatigue strength, which showed that static strength and fatigue strength of the bogie frame met the requirements of design and operation.