Aiming at the effect of railway parameters on wheel wear of locomotive, D20E type diesel locomotive dynamics model was built by SIMPACK software. A model combined locomotive dynamics, FASTSIM algorithm and Zobory profile wear model was built, and wheel tread wear simulation program was developed. The effect of railway parametes on wheel wear was analyzed. The results indicated that, the wheel wear depth decreased rapidly with the increase of curve radius; the wear depth obviously decreased and the wear distribution range increased with the increase of rail gauge; the wheel wear depth in America five grade railway, America six grade railway was less than that in America four grade railway; the wear distribution range increased with the worse grade railway; the rail cant was reduced properly, wheel wear would be decreased; decreasing properly the friction coefficient could favorably reduce wheel wear.