For decreasing the train operation resistance force, key technologies of high-speed EMUs aero-dynamical design and lightweight design were studied. By the systematic analysis and optimization of the major factors to influence train operation resistance force, control scheme and practical measures were proposed for high-speed EMUs noise reduction and weight lightening. Line test showed that the provided measures reduced high-speed EMUs operation resistance force effectively, realized speed lifting, energy conservation and environmental protection, and improved train dynamics performance and synthetical comfort too.